dxa machine discovery w  (Hologic Inc)

Journal: The Journal of Clinical Endocrinology and Metabolism

Article Title: Diagnostic Value of Anthropometric Measurements for Familial Partial Lipodystrophy, Dunnigan Variety

doi: 10.1210/clinem/dgaa137

Figure Lengend Snippet: Comparison of skinfold thickness values of FPLD2 subjects from UT Southwestern Medical Center cohort with the NHANES controls. Solid symbols signify subjects with “typical” LMNA variants vs unfilled symbols indicating “atypical” LMNA variants in females (circles) and males (squares). The data from the NHANES controls have been drawn as a percentile chart for comparison. (A) Female FPLD2 subjects have subscapular skinfold thickness values in the 5th to 95th percentile, except for 1 subject who had less than 1st percentile. (B) Male FPLD2 subject have subscapular skin folds in the 25th to 75th percentile with no specific trend. (C) The triceps skinfold measurements are <1st percentile in the majority of the female FPLD2 subjects except for 5 patients. (D) All 5 males with FPLD2 had triceps skin fold values in 5th to 50th percentile with no specific trend. FPLD2, familial partial lipodystrophy, Dunnigan variety; NHANES, National Health and Nutrition Examination Survey.

Article Snippet: For the UTSW cohort, whole-body DXA examinations were acquired on Discovery W (S/N 80502) model machine according to the procedures recommended by the manufacturer (Hologic, Inc., Bedford, MA) ( 19 , 20 ).

Techniques: Comparison

Journal: The Journal of Clinical Endocrinology and Metabolism

Article Title: Diagnostic Value of Anthropometric Measurements for Familial Partial Lipodystrophy, Dunnigan Variety

doi: 10.1210/clinem/dgaa137

Figure Lengend Snippet: Comparison of regional body fat (by dual-energy x-ray absorptiometry scan) of FPLD2 subjects from UTSW cohort with the NHANES controls. Solid symbols signify subjects with “typical” LMNA variants vs unfilled symbols indicate those with “atypical” LMNA variants in females (circles) and males (squares). The data from the NHANES controls have been drawn as age-specific percentile values for comparison. (A) The upper limb fat was <5th percentile in most of the affected females except in five patients with atypical LMNA variants and in four with typical LMNA variants had higher values. (B) The upper limb fat ranged between the 1st and 25th percentile in the affected males. (C) All affected females, except 2, had lower limb fat ≤1st percentile of NHANES. Of the 2 exceptions, 1 patient had a p.G523R (atypical) variant; the other had a p.R482Q (typical) variants but had excess fat accumulation in the medial part of the thighs and knees. (D) The lower limb fat in the affected males was below the 25th percentile of NHANES. (E) Truncal fat ranged between the 1st and 75th percentile in most of the affected females. (F) The truncal fat ranged between the 1st and 75th percentile in the affected males. (G) The ratio of lower limb fat/truncal fat was ≤1st percentile (≤0.85) of NHANES in all affected females, except in 1 patient with a p.G523R (atypical) variant; and the other with a p.R482Q (typical) variant. (H) The ratio of lower limb fat/truncal fat was <25th percentile of NHANES in all affected males. NHANES, National Health and Nutrition Examination Survey; UTSW, UT Southwestern Medical Center.

Article Snippet: For the UTSW cohort, whole-body DXA examinations were acquired on Discovery W (S/N 80502) model machine according to the procedures recommended by the manufacturer (Hologic, Inc., Bedford, MA) ( 19 , 20 ).

Techniques: Comparison, Variant Assay

Journal: Bone

Article Title: Adaptation of the proximal humerus to physical activity: a within-subject controlled study in baseball players

doi: 10.1016/j.bone.2019.01.008

Figure Lengend Snippet: Proximal humerus propertie s in the throwing and non-throwing arms

Article Snippet: Areal properties of the bilateral proximal humeri were obtained in all participants using DXA (Discovery-W machine with Apex v2.3 software; Hologic, Inc., Waltham, MA, USA), as previously described.

Techniques: Imaging

Journal: Bone

Article Title: Adaptation of the proximal humerus to physical activity: a within-subject controlled study in baseball players

doi: 10.1016/j.bone.2019.01.008

Figure Lengend Snippet: Effect of throwing-related physical activity on DXA-derived proximal humerus areal bone mineral density (aBMD), bone mineral content (BMC), and bone area. Data represent the mean percent difference between throwing and nonthrowing arms, with error bars indicating 95% confidence intervals. Confidence intervals greater than 0% indicate greater bone properties within the throwing arm compared to nonthrowing arm (†p < 0.01).

Article Snippet: Areal properties of the bilateral proximal humeri were obtained in all participants using DXA (Discovery-W machine with Apex v2.3 software; Hologic, Inc., Waltham, MA, USA), as previously described.

Techniques: Activity Assay, Derivative Assay